When consuming Cannabis it is worthwhile noting the bioavailability of the constituents being consumed. Bioavailability refers to the extent and rate at which the active ingredients access the site of action (Le, 2022). The following is a list of the bioavailability of the main constituents in Cannabis and the two most common Cannabis consumption routes (Chayasirisobhon, 2020) (McGilveray, 2005) (Lim, et al., 2020):

• Ingested THC = 4-13% bioavailability. A maximum bioavailability of 95% can be achieved using oral dronabinol (a naturally or synthetically produced THC).
• Inhaled THC = 10-35% bioavailability. A maximum bioavailability of 69% can be achieved using a smoking machine (e.g., a vaporiser).
• Ingested CBD = 6-16% bioavailability.
• Inhaled CBD = 11-45% bioavailability.

There are many different manors of preparing and administering Cannabis and its constituents. They can be broadly summarised as oral (e.g., capsules), inhaled (e.g., vapes), sublingual (e.g., tinctures), ophthalmic (e.g., eye drops) and rectal (e.g., suppositories). Table 1 summarises preparations that have been researched and their associated general dosages for different medical indications (Amar, 2006) (Hazekamp & Grotenhermen, 2010) (Kowal, et al., 2016) (Legare, et al., 2022).